Nitazenes are synthetic opioids similar to fentanyl but can match or surpass the potency of fentanyl.

The Drug Enforcement Administration (DEA) presents the 2025 National Drug Threat Assessment (NDTA), a comprehensive report that provides a national-level perspective on the threats posed by deadly illicit drugs and the violent transnational criminal organizations responsible for producing the drugs poisoning our communities. This annual assessment provides valuable strategic drug-related...

Mexican cartels, primarily the Sinaloa Cartel and Jalisco New Generation Cartel (CJNG), are increasingly targeting illicit drug markets in Australia and New Zealand. In collaboration with organized crime groups (OCGs) and money laundering organizations (MLOs) in Australia and New Zealand, cartels are capitalizing on the highly lucrative methamphetamine and cocaine...

The most significant drug-related threat to Wisconsin is posed by Mexican drug trafficking organizations (DTO), particularly the Cartel de Sinaloa (CDS) and the Cartel de Jalisco Nueva Generación (CJNG). Mexican DTOs dominate the wholesale supply of illicit opioids (both fentanyl and heroin), cocaine, methamphetamine, and Mexico-grown marijuana in the state...

Due to the similarities of medetomidine and dexmedetomidine to xylazine — medetomidine is used in a similar manner as xylazine in veterinary medicine, and dexmedetomidine in human practice and veterinary medicine — DEA assesses both drugs have the potential to be supplements to or replacements for xylazine in terms of...

The most significant drug-related threat to Illinois is posed by Mexican drug trafficking organizations (DTOs), particularly the Cartel de Sinaloa (CDS) and the Cartel de Jalisco Nueva Generación (CJNG). Mexican DTOs dominate the wholesale supply of illicit opioids (fentanyl and heroin), cocaine, methamphetamine, and Mexico grown marijuana in the state.

The most significant drug-related threat to Indiana is posed by Mexican drug trafficking organizations (DTO), particularly the Cartel de Sinaloa (CDS) and the Cartel de Jalisco Nueva Generación (CJNG). Mexican DTOs dominate the wholesale supply of illicit opioids (both fentanyl and heroin), cocaine, methamphetamine, and Mexico-grown marijuana in the state...

DEA has prepared this product primarily for law enforcement counterparts (state, local and tribal) and public safety and protection officials with a focus on enduring and emerging threats at both the national and regional levels. This report represents what will be the first of regular STREET reports prepared for and...

The 2024 National Drug Threat Assessment (NDTA) is a comprehensive strategic assessment of illicit drug threats endangering the United States. DEA’s goal in publishing the NDTA is to save American lives by raising awareness and understanding of these threats. This annual assessment provides law enforcement agencies, policy makers, and prevention...

DEA has prepared this product primarily for law enforcement counterparts (state, local and tribal) and public safety and protection officials with a focus on enduring and emerging threats at both the national and regional levels. This report represents what will be the first of regular STREET reports prepared for and...