One Pill Can Kill

* 2 mg of fentanyl equates to a potentially deadly dose

DEA Fentanyl Seizures in 2025

In 2024, DEA seized more than 60 million fentanyl-laced fake pills and nearly 8,000 pounds of fentanyl powder. The 2024 seizures are equivalent to more than 377 million lethal doses of fentanyl.

The 2025 fentanyl seizures represent over 81 million deadly doses. *

Millions of Fentanyl Pills Seized

+ 13500000

Pounds of Fentanyl Powder Seized

+ lbs. 2132

* 2 mg of fentanyl equates to a potentially deadly dose

Stand Up. Speak Out. Fight Back.

DEA is using innovative ways to get the One Pill Can Kill message out.

Join in the Fight to Save Lives

Whether you're a teacher, influencer, first responder, parent, or student leader, your advocacy matters.

Learn More

Step Up. Speak Out. Fight Back

The U.S. Drug Enforcement Administration has teamed up with NFL Alumni Health to spread its important message, One Pill Can Kill.

Learn More

DEA ‘One Pill Can Kill’ Campaign Championed by NFL Alumni Health

NEW ORLEANS – With so much attention ahead of Sunday’s big game, the U.S. Drug Enforcement Administration is once again teaming up with NFL Alumni Health to encourage football fans to join us in the fight to save lives. The need is critical and the game plan simple: understand the dangers of fentanyl and synthetic drugs and use your voice to help spread life-saving information.

Can You Spot the Fake?

Never trust your own eyes to determine if a pill is legitimate. The only safe medications are ones prescribed by a trusted medical professional and dispensed by a licensed pharmacist.

Deadly Dose

2mg, the amount on the tip of this pencil, can be enough to kill an average American.

Fentanilo_Aunténtica_dosis_letal_en_un_lápiz.jpg

Resources

Info for Teens

Info for Parents & Caregivers

Info for Teachers

Info for Seniors

Save Lives with Naloxone

Naloxone is a medicine that rapidly reverses an opioid overdose. It is an antagonist. This means that it attaches to opioid receptors and reverses and blocks the effects of other opioids. Naloxone can quickly restore normal breathing to a person if their breathing has slowed or stopped because of an opioid overdose.

One Pill Can Kill Stories

Teens Speak Out

A Mom Speaks Out

Share One Pill Can Kill Materials

Share One Pill Can Kill Materials with Your Friends, Family, Community, and Workplace

Social Media Resources

DEA created this campaign to encourage the use of social media to help raise public awareness of a significant nationwide surge in counterfeit pills that are mass-produced in labs, deceptively marketed as legitimate, and are killing Americans at an unprecedented rate.

View Social Media Resources

Partner Toolbox

The One Pill Can Kill Campaign offers an opportunity for the media, parents, teachers, educators, and community organizations to raise awareness about counterfeit prescription drugs. DEA has created materials to help you participate in raising awareness.

View Partner Toolbox